Research Associate/Senior Research Associate
Appia Bio
Culver City, CA, USA · Culver City, CA, USA
Posted on Feb 8, 2025
About Our Company
Appia Bio is a preclinical stage biotech company founded in 2020 with the mission to bring innovative off-the-shelf cell therapies to patients with cancer and autoimmune diseases. Our novel platform can generate a broad array of allogeneic T cell types which can be further engineered to address challenges in tumor microenvironments. Our goal is to discover and develop allogeneic cell therapies across a broad array of disease indications with a scalability that increases access for patients.
Our compelling research programs are rooted in leveraging T cell biology to generate differentiated NKT and gamma delta T cells from hematopoietic stem cells. The management team brings decades of experience in R&D and business in the biotech industry.
Company Overview
Appia Bio is a preclinical stage biotech company founded in 2020 with the mission to bring innovative off-the-shelf cell therapies to patients with cancer and autoimmune diseases. Our novel platform can generate a broad array of allogeneic T cell types which can be further engineered to address challenges in tumor microenvironments. Our goal is to discover and develop allogeneic cell therapies across a broad array of disease indications with a scalability that increases access for patients.
Our compelling research programs are rooted in leveraging T cell biology to generate differentiated NKT and gamma delta T cells from hematopoietic stem cells. The management team brings decades of experience in R&D and business in the biotech industry.
Job Title
Research Associate/Senior Research Associate; Analytical Sciences; Technical Operations
Job Overview
Appia’s Analytical Sciences team is seeking a passionate and innovative Research Associate/Senior Research Associate. The candidate will be responsible for developing cell-based analytical methods aligned with vector and allogeneic cellular therapy product quality attributes to enable process development, product characterization, stability and release testing of Appia Bio’s novel engineered cell therapy products. In addition, they will author and review method development reports, standard operating procedures, gap and risks assessments, and assist in the technical review of documents supporting regulatory filings. The final title will be based on a combination of education and experience.
Responsibilities And Duties
Appia Bio is proud to be an equal opportunity workplace. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.
“Beware of scams. Please confirm that you are applying to a job listed here and interviewing on-site prior to job offers. We do not ask for purchases as part of onboarding.”
Final compensation for the successful candidate is determined by various factors, including educational credentials and relevant job or industry experience. The advertised pay range is indicative and generally applicable to candidates meeting the job description's criteria. In line with our commitment to fairness and competitive compensation, we will consider your unique skill set and overall profile. Additionally, we offer a comprehensive benefits program designed to meet your individual needs.
Culver City Pay Range
$80,000 - $121,200 USD
Benefits
Competitive Compensation Packages | Cost Sharing for Health Insurance Premiums | Flexible Work Environment | Untracked PTO | 401(k) Retirement Savings Plan Match | Life Insurance & Disability| Awesome Culture | Challenging & Fulfilling Work | Equity Options | and more
Appia Bio requires COVID-19 vaccination for all employees. As required by applicable law, we will consider requests for reasonable accommodations.
The statements herein are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of personnel so classified. In addition, Appia Bio only extends offers of employment to candidates that have been through a formal selection process.
Appia Bio is proud to be an equal opportunity workplace. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.
Appia Bio is a preclinical stage biotech company founded in 2020 with the mission to bring innovative off-the-shelf cell therapies to patients with cancer and autoimmune diseases. Our novel platform can generate a broad array of allogeneic T cell types which can be further engineered to address challenges in tumor microenvironments. Our goal is to discover and develop allogeneic cell therapies across a broad array of disease indications with a scalability that increases access for patients.
Our compelling research programs are rooted in leveraging T cell biology to generate differentiated NKT and gamma delta T cells from hematopoietic stem cells. The management team brings decades of experience in R&D and business in the biotech industry.
Company Overview
Appia Bio is a preclinical stage biotech company founded in 2020 with the mission to bring innovative off-the-shelf cell therapies to patients with cancer and autoimmune diseases. Our novel platform can generate a broad array of allogeneic T cell types which can be further engineered to address challenges in tumor microenvironments. Our goal is to discover and develop allogeneic cell therapies across a broad array of disease indications with a scalability that increases access for patients.
Our compelling research programs are rooted in leveraging T cell biology to generate differentiated NKT and gamma delta T cells from hematopoietic stem cells. The management team brings decades of experience in R&D and business in the biotech industry.
Job Title
Research Associate/Senior Research Associate; Analytical Sciences; Technical Operations
Job Overview
Appia’s Analytical Sciences team is seeking a passionate and innovative Research Associate/Senior Research Associate. The candidate will be responsible for developing cell-based analytical methods aligned with vector and allogeneic cellular therapy product quality attributes to enable process development, product characterization, stability and release testing of Appia Bio’s novel engineered cell therapy products. In addition, they will author and review method development reports, standard operating procedures, gap and risks assessments, and assist in the technical review of documents supporting regulatory filings. The final title will be based on a combination of education and experience.
Responsibilities And Duties
- Employ quality by design (QbD) and design of experiment (DOE) approaches to quickly identify robust operating regions within phase-appropriate pre-defined acceptance criteria aimed to meet ICH guidelines
- Execute and document analytical method development activities and assay execution for the following techniques (depending on candidate’s expertise) towards enabling process development and product understanding
- cell culture/passaging
- immunophenotyping using multi-parametric flow cytometry
- plate-based immunoassays
- droplet digital PCR
- Work with Process Development in executing and documenting analytical methods as part of experimental study plans supporting the process development of Appia’s novel cell therapy platforms
- Author, review, and edit accurate technical documents related to method development & qualification, equipment usage, and training
- Assist in technology transfer of analytical methods to contract manufacturing and development organizations and/or external business partners
- Participate in group and department meetings by presenting scientific data and communicating expertise in areas of responsibility
- Maintain, calibrate, and operate analytical equipment and instrumentation that is used routinely in the execution of assays
- Ensure that departmental area is maintained per 5S guidelines
- Other duties as assigned
- S. in Immunology, Cell Biology, or related discipline or in a similar discipline with 3-8+ years of industry experience.
- Demonstrate expertise with developing and/or executing any or all of the following analytical methods
- plate-based immunoassays (e.g. ELISA, MSD, Luminex, AlpaLISA)
- multi-parametric flow cytometry
- mammalian cell-based potency assays (e.g co-culture, cytotoxicity, proliferation)
- droplet digital PCR using the QX200 (Bio-Rad)
- Experience with Good Documentation Practices and analytical method development for execution in a GMP environment
- Excellent skills in Microsoft Office and data analysis software (e.g. Prism, JMP, FlowJo, CytExpert, SoftMax Pro)
- Ability to think critically and demonstrate troubleshooting and problem-solving skills
- Excellent interpersonal, verbal, and written communication skills
- Experience and aptitude in working in a multidisciplinary, fast-paced laboratory environment with moderate supervision
- Demonstrate knowledge of process development of cellular therapy products and analytical method development for GMP
- Experience in development and qualification of immunoassays, multi-parameter flow cytometry, and potency methods for release in a QC/regulated environment
Appia Bio is proud to be an equal opportunity workplace. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.
“Beware of scams. Please confirm that you are applying to a job listed here and interviewing on-site prior to job offers. We do not ask for purchases as part of onboarding.”
Final compensation for the successful candidate is determined by various factors, including educational credentials and relevant job or industry experience. The advertised pay range is indicative and generally applicable to candidates meeting the job description's criteria. In line with our commitment to fairness and competitive compensation, we will consider your unique skill set and overall profile. Additionally, we offer a comprehensive benefits program designed to meet your individual needs.
Culver City Pay Range
$80,000 - $121,200 USD
Benefits
Competitive Compensation Packages | Cost Sharing for Health Insurance Premiums | Flexible Work Environment | Untracked PTO | 401(k) Retirement Savings Plan Match | Life Insurance & Disability| Awesome Culture | Challenging & Fulfilling Work | Equity Options | and more
Appia Bio requires COVID-19 vaccination for all employees. As required by applicable law, we will consider requests for reasonable accommodations.
The statements herein are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of personnel so classified. In addition, Appia Bio only extends offers of employment to candidates that have been through a formal selection process.
Appia Bio is proud to be an equal opportunity workplace. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.